O20: Biomarkers for Epilepsy
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Epilepsy biomarkers.
A biomarker is defined as an objectively measured characteristic of a normal or pathologic biologic process. Identification and proper validation of biomarkers of epileptogenesis (the development of epilepsy) and ictogenesis (the propensity to generate spontaneous seizures) might predict the development of an epilepsy condition; identify the presence and severity of tissue capable of generating...
full textA review on the most valuable biomarkers in epilepsy
Background & Objective: Epilepsy is a common neurological disorder with the prevalence of 50 million in the world. Despite of many researches and introducing of different anti-epileptic drugs, 30% of patients suffer from refractory seizures. Biomarkers are the measurable indicators to detect the physiological and pathological condition. Biomarkers in epilepsy can be utilized for prediction, dia...
full textWONOEP appraisal: Imaging biomarkers in epilepsy.
Neuroimaging offers a wide range of opportunities to obtain information about neuronal activity, brain inflammation, blood-brain barrier alterations, and various molecular alterations during epileptogenesis or for the prediction of pharmacoresponsiveness as well as postoperative outcome. Imaging biomarkers were examined during the XIII Workshop on Neurobiology of Epilepsy (XIII WONOEP) organize...
full textCirculating microRNAs are promising novel biomarkers for drug-resistant epilepsy
MicroRNAs (miRNAs) open up a new field for molecular diagnosis for cancer and other diseases based on their stability in serum. However, the role of circulating miRNAs in plasma/serum in epilepsy diagnosis is still unclear. The aim of this study was to evaluate whether miRNAs can be used as biomarkers for drug-resistant epilepsy. We measured the differences in serum miRNA levels between 30 drug...
full textGenome-wide circulating microRNA expression profiling indicates biomarkers for epilepsy
MicroRNAs (miRNAs) have been proposed as biomarkers for cancer and other diseases due to their stability in serum. In epilepsy, miRNAs have almost been studied in brain tissues and in animals' circulation, but not in circulation of human. To date, a major challenge is to develop biomarkers to improve the current diagnosis of epilepsy. The aim of this study was to evaluate whether circulating mi...
full textAdvances in the development of biomarkers for epilepsy.
Over 50 million people worldwide have epilepsy. In nearly 30% of these cases, epilepsy remains unsatisfactorily controlled despite the availability of over 20 antiepileptic drugs. Moreover, no treatments exist to prevent the development of epilepsy in those at risk, despite an increasing understanding of the underlying molecular and cellular pathways. One of the major factors that have impeded ...
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Journal title
volume 6 issue 3
pages 20- 20
publication date 2018-07
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